THBS1 and ischemic stroke: During an AIS, increased expressions of TSP-1 and TSP-2 at the level of mRNA and protein, which exhibited different profiles of temporal expression, were confirmed in a study by Navarro-Sobrino et al. [48], where increased thrombospondin-2 levels on admission in patients with ischemic stroke and increased thrombospondin-1 levels two hours after treatment with tissue plasminogen were identified.