Given that patients suffering by systemic autoimmune diseases display an excessive burden for subclinical atherosclerosis [3,4,5,6], the aim of our study was to examine whether four MFGE8 variants—previously linked to autoimmunity development in a Taiwanese study—(Figure 1A) and MFGE8 serum levels are associated with autoimmune disease susceptibility, as well as autoimmune-related atherosclerosis in Caucasian patients [7]. This evidence concerns the gene MFGE8 and autoimmune disease.