Like hesperidin, ponciretin has shown anticancer and anti-inflammatory effects, with cytotoxic effects on a colon cancer cell line in vitro [27] and attenuating colitis in mice by the anti-inflammatory effects of suppressing NF-κB activation and correcting the imbalance of Th17/Treg cells [33,34]. The gene discussed is NFKB1; the disease is malignant colon neoplasm.