NR4A3 and cancer: In addition, the most significantly differentially expressed genes in the TS35-vs-TS45 results were mainly related to vascular protection (Nr4a3, SCN3B) and maintaining or changing tissue morphology (DDIT4L, Myh6), which might be due to the adaptation stage of acute hypoxia stress from 3500 m to 4500 m altitude, similar to the slow downstage of cancer cell proliferation.