A wide variety of proinflammatory cytokines, such as IL-1β, IL-2, IL-6, IL-12 and tumor necrosis factor (TNF-α), in addition to some antibodies (ribosomal antibody-P and anti-N-receptor methyl-D-aspartate) interfere in the mediation of the inflammatory processes of depression [51]. The gene discussed is TNF; the disease is depressive disorder.