TNF and Obesity: These results were further supported herein by the identification of signalling pathways such as NF-κB, HIF-1α, and AGE-RAGE, all induced as highlighted from the bio-informatics analysis, and where the upregulation of IL-6 connected pathways was modulated by obesity-like insulin resistance, TNF signaling, AGE-RAGE, and cytokine-receptor interaction (Figure 1).