To understand the role of adipocytes in tumor progression, previous studies have co-cultured human breast cancer cells with human mature adipocytes [6,24,39], leading to an increase in the invasiveness of the cancer cells, and the onset of a pro-inflammatory state characterized by the induction of cytokines such as IL-6, IL-1β, and CCL5 [24,39]. Here, IL1B is linked to breast cancer.