FADS2 and alcohol dependence: It was found that the direct effect of the FADS1 and FADS2 gene polymorphisms on gestational weight, adjusted for pre-gestational BMI, maternal age, years of schooling, maternal alcoholism, and gestational week, varied significantly; however, only the rs174575 (FADS2) SNP showed a positive and significant direct effect on weight throughout pregnancy (0.11), indicating that pregnant women homozygous for the minor allele and heterozygotous for this SNP have a higher risk of gestational weight gain (Table 2).