FADS2 and obesity due to melanocortin 4 receptor deficiency: The results of the present study are in agreement with this theory, and other empirical investigations have also reported similar results, revealing that individuals homozygous for the minor allele of the rs174575 (FADS2) and rs174561 (FADS1) SNPs exhibit lower activity of the desaturase enzymes, with a plasma increase of LA and ALA and a reduction of ARA, EPA, and DHA [10,12,13], which may provide higher levels of arachidonic acid and inflammatory disorders [15,16] due to increased LA and reduced EPA and DHA, as well as increased body weight and/or obesity [12,29].