The top relevant diseases and biological functions affected by HFD + W treatment in aorta and heart tissues included the following: blood coagulation (C3, C9, F12, and F9), homeostasis of iron (CP and TF), complement activation (C3 and CFB), transport of transition metal ions (CP and TF), complement-mediated lysis of red blood cells (CFB), classical complement pathway (C3), transport of iron ion (TF), transport of Cu2+ (CP), myocardial infarction (C3), and contraction of aortic ring tissue (HPX). The gene discussed is C3; the disease is myocardial infarction.