The GCF Interleukin-6 (IL-6) levels showed statistically significant decreases with probiotic supplementation compared to controls in patients with periodontal disease (SMD = 0.361, 95% CI: 0.079, 0.644, I2 < 0.001, p-value ≤ 0.05, and n = three studies). Here, IL6 is linked to periodontal disorder.