In addition, Kim et al. [23], reported that quercetin inhibited osteoclastogenesis, reduced RANKL levels, and decreased RANKL and IL-17-induced differentiation of monocytes to osteoclasts in multiple ways, and could be potentially used as an alternative therapeutic agent in regulating bone destruction and inflammation in rheumatoid arthritis. This evidence concerns the gene TNFSF11 and rheumatoid arthritis.