According to the ICON and EAACI guidelines for food allergies [40], the diagnosis of peach allergy lies on the combination of a convincing clinical history of immediate reaction to peach and positive IgE sensitization testing assessed through SPT to peach (in the form of either extract, molecular components, or fresh peach), and/or IgE sensitization to peach (either extracts or molecular components). This evidence concerns the gene IGHE and food allergy.