SOST and type 2 diabetes mellitus: Interestingly, increased levels of sclerostin were found both in serum and bone specimens of patients with type 2 diabetes [51,52], post-menopausal women compared to pre-menopausal ones [22,53], immobilized postmenopausal women with bone resorption markers elevation [54] and postmenopausal women with osteoporosis compared to postmenopausal women without osteoporosis, even if no correlation was seen with BMD [55].