L1CAM and esophageal squamous cell carcinoma: Consistent with decreased MMP-9 levels, C-PAC and AFG decreased expression of L1CAM in JHAD1 cells, a neuronal adhesion protein linked to metastasis and chemoresistance, and is overexpressed in many solid tumor cancers including esophageal squamous cell carcinoma and gastric cancer [81,82,83].