MTOR and obesity due to melanocortin 4 receptor deficiency: Many studies report natural sources of terpenoids for anti-obesity, such as carnosic acid and 14-deoxy-11,12-didehydroandrographolide, isolated from Andrographis paniculata, which displays inhibitor adipocyte differentiation by decreasing the gene expression of C/EBPα and PPAR-γ and upregulating mTOR pathways [39].