On a hard surface, the Hippo pathway is involved in the proliferation of tumor cells, consisting of three main components: large tumor suppressor 1/2 (LATS1/2), yes-associated transcriptional regulator/tafazzin (YAP/TAZ) and mammalian Ste20-like kinases 1/2 (MST1/2). This evidence concerns the gene LATS1 and neoplasm.