In detail, on the stiffer matrix, the ILK-integrin signal inhibits the activity of myosin phosphatase target subunit 1 and suppresses the signaling cascade of Merlin, MST1/2, and LATS1/2 [128], which results in the YAP/TAZ translocation to the nucleus from the cytoplasm [129] and initiated cell proliferation gene (such as cyclin D1 and forkhead box M1) transcription, where they initiate the transcription of genes involved in tumor cell proliferation. The gene discussed is TAFAZZIN; the disease is neoplasm.