CD68 and classic Hodgkin lymphoma: High levels of macrophages, their associated markers (morphology, CD68, ALDH1A1, MMP11, and LYZ/STAT1 expression), and their gene expression profiles, are recurrently observed in cHL patients associated with poor outcomes [2,5,9,27,58,66], although the CD68 analysis leads to conflicting results [21,67,68].