The role of the nuclear factor-kappa B (NF-κB) signaling pathway in the pathogenesis of NSCLC has been elucidated in animal models, and both receptor activator of nuclear factor-kappa (RANK) and NF-κB function to promote cancer with bone metastases [82,83,84,85,86]. The gene discussed is TNFRSF11A; the disease is non-small cell lung carcinoma.