Non-coding mi-RNA plays an important role in tumorigenesis and progression of cancer by interfering with various cell signaling pathways, including, WNT/beta-catenin, phosphoinositide-3-kinase (PI3 K)/protein kinase B (Akt), epidermal growth factor receptor (EGFR), NOTCH1, mechanistic target of rapamycin (mTOR), and TP53. The gene discussed is AKT1; the disease is cancer.