ITIH4 and neoplasm: In the early detection of CRC, ML-based AI can help isolate circulating tumor cells in peripheral smear and analyze serum specific biomarkers, such as leucine-rich alpha-2-glycoprotein 1 (LRG1), EGFR, inter-alpha trypsin inhibitor heavy chain family member 4 (ITIH4), hemopexin (HPX), and superoxide dismutase 3 (SOD3) [87,88].