Regarding the mutational profile in patients with AA-LGLL, Jerez et al., in their cohort of 140 patients with AA, found 11 (7.9%) cases with known LGLL, of which six (54.5%) had STAT3 mutations, along with 10 (7.1%) patients mutated for STAT3 without suspicion of LGLL. Here, STAT3 is linked to T-cell large granular lymphocyte leukemia.