In addition, the analysis of a cohort of 16 patients presenting a JMML-like phenotype without mutations in any of the five canonical JMML genes revealed three patients that harbored gain-of-function ALK and ROS1 tyrosine kinase fusions, including RANBP2-ALK, DCTN1-ALK, and TBL1XR1-ROS1 [37]. The gene discussed is ROS1; the disease is juvenile myelomonocytic leukemia.