AKAP12 and juvenile myelomonocytic leukemia: In addition to the genes identified in these studies, hypermethylation in other genes such as RASA4, CREBBP, and AKAP12 was also observed in JMML patients in correlation with a poor survival and high risk of relapse after HSCT, further supporting the significance of DNA methylation in aggressive JMML phenotypes (Table 2; Figure 4) [96,97,98].