Germline NF1 mutations are associated to neurofibromatosis type 1, a common autosomal congenital disorder characterized by the presence of café-au-lait macules, skinfold freckling, development of tumors of the nervous system, and overlapping features with other RASopathies, such as NS and Legius syndrome [56]. This evidence concerns the gene NF1 and neurofibromatosis type 1.