In addition, its role in B4GALT1 on HCC formation and its association with HCC-related IgG glycan alteration are further explored by performing cancer induction in CD19-cre+/− B4GALT1flox/flox mice and in B4GALT1-deficient (B4GALT1+/−) mice. The gene discussed is B4GALT1; the disease is cancer.