STAT3 is an oncogene that mediates gene expression and metabolic regulations in various human solid tumors and hematologic malignancies and plays an important role in the growth, proliferation, survival, maintenance, and self-renewal of cancer stem cells (CSCs) [3,4,5,6,7], which are also capable of differentiating and maintaining tumor heterogeneity. The gene discussed is STAT3; the disease is neoplasm.