EGFR and colorectal cancer: Finally, a combination of KRAS-G12C inhibitors (adagrasib, ARS-1620) with EGFR targeted therapies (gefitinib, afatinib) was found to reduce downstream MAPK signaling (P-MEK and P-ERK) in vitro as well as in vivo, to reduce tumors in vivo in mouse xenografts, especially in colorectal cancer cells lines [11,42].