Recent studies have revealed that the inhibition of NK1R suppresses cell proliferation and induces apoptosis in the stem-like cells of several cancers, such as esophageal squamous cell carcinoma (ESCC), by blocking the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor-kappa B (NF-κB) pathway [32]. This evidence concerns the gene NFKB1 and esophageal squamous cell carcinoma.