The accumulation of glutamine carbons in glutamate rather than in TCA cycle intermediates emphasizes the importance of glutamine and glutamate as key amino acids for MYC-driven medulloblastoma and is concordant with our finding that these tumor cells use glucose carbons via the TCA cycle to synthesize glutamate and glutamine (Figure 3E and Figure 4C). The gene discussed is MYC; the disease is medulloblastoma.