In this line, “CSPG4-high” GIST, as compared to “CSPG4-low” GIST, might be more sensitive to CSPG4-CAR.CIKs, not only because of higher target expression level, but also thanks to a more favorable anti-tumor cytokine microenvironment with a synergic action of resident cytotoxic T and NK cells. The gene discussed is CSPG4; the disease is neoplasm.