We found significant variations between the two tumor groups, with higher expression of several immune variables in “CSPG4-high” tumors: (i) higher scores for immune signatures suggesting higher infiltration by immune cells; (ii) higher infiltrate in certain immune cell subtypes: DC, T cells, Tem, CD8 T cells, and numerous cytotoxic cells subsets, such as activated NK CD56dim cells; (iii) higher expression of signatures evoking higher immune cytolytic activity. The gene discussed is CSPG4; the disease is neoplasm.