NPM1 and acute myeloid leukemia: In the field of hematology, studies of liquid biopsies, in terms of CTC, have been carried out over the last few years, such as in CML (with a treatment adjustment in terms of BCR/ABL1 peripheral blood leukocyte RNA in CML patients, as well as adjustments in terms of the NPM1-mutated ratio in peripheral blood leukocyte RNA in AML).