MYD88 p.L265P mutation was found in tumor-derived DNA from all 14 patients (14/14, 100%)Among 14 cell-free DNAs evaluated by ddPCR (14/14) and TDS (13/14), the MYD88 L265P mutation was detected in eight out of 14 (ddPCR) and in 0 out of 13 (TDS) samples, respectivelyAfter chemotherapy, the MYD88 L265P mutation in cell-free DNA was traced to five patients; the mutations disappeared after chemotherapy, and they remained undetectable in all patients. This evidence concerns the gene MYD88 and neoplasm.