MBTPS1 and pancreatic adenocarcinoma: To evaluate whether increasing the plasma S1P level would enhance the sensitivity of pancreatic cancer tumors to gemcitabine chemotherapy, the effect of the combination of LX2931 with gemcitabine was evaluated in vivo in the TPAN1-IFA human patient-derived pancreatic adenocarcinoma xenograft model (Figure 6).