The knockdown of lncRNA MIR4435-2HG expression inhibited prostate cancer cell malignant properties in vitro and in vivo, whereas the inhibition of ST8SIA1 expression decreased the effects of miR4435-2HG, both in vitro and in vivo, by blocking the activation of the FAK/AKT/β-catenin pathway [44]. This evidence concerns the gene PTK2 and Familial prostate cancer.