In SK MEL-2 melanoma cells, the promoter region lacks TATA and CAAT boxes, but contains putative binding sites for general transcription factors associated with cancers and inflammation (c-Ets-1, CREB, AP-1, NF-κB), with a crucial role of NF-κB in ST8SIA1 expression in SK-MEL-2 cells (Figure 1). The gene discussed is NFKB1; the disease is melanoma.