PTK2 and Familial prostate cancer: The long non-coding (lnc) RNA MIR4435-2HG that binds to the ST8SIA1 gene is highly expressed in several cancers (lung, bladder, liver, prostate, stomach) and activates the FAK/AKT/B-catenin pathway in prostate cancer cells; furthermore, interfering with either ST8SIA1 or MIR4435-2HG expression inhibited the malignant properties of cells both in vitro and in vivo [44].