Another mechanism of ST8SIA1 regulation involves non-coding RNA (the non-coding RNA microRNA-33a (miR-33a) and has-let-7e (let-7e) can bind to the 3′-untranslated (3′-UTR) region of ST8SIA1), and their downregulation in colorectal cancer may contribute to higher ST8SIA1 expression and increased cell motility and viability [43]. This evidence concerns the gene ST8SIA1 and colorectal cancer.