Among the ECM and ECM-related genes that were differentially expressed in the stromal–epithelial samples (n = 255), only 15 of them were significantly expressed, with the majority being upregulated in the STS subjects (Figure 5, FDR < 0.05), including CTSH, S100A2, SERPINE1, WNT7B, GPC3, and a number integrins (ITGA3 and ITGA6). The gene discussed is S100A2; the disease is telomere syndrome.