A more recent study proposed pharmacologically induced TH inactivation as a strategy to reduce tumour metastatic potential based on their observation that T3 promoted epithelial–mesenchymal transition by the transcriptional activation of ZEB-1, mesenchymal genes, and MMPs and suppression of E-cadherin, thereby influencing tumour progression and metastasis in skin squamous cell carcinoma [66]. This evidence concerns the gene ZEB1 and neoplasm.