Secondly, overexpression of lysyl oxidase-like 1 (LOXL-1) in a non-small cell lung cancer metastasis model was associated with the upregulation of MCT1/2, increased expression and activity of MMP2/9, and increased cell migration and invasion, along with increased extracellular lactate at a low pH [27]. This evidence concerns the gene LOXL1 and non-small cell lung carcinoma.