TERT and central nervous system cancer: H3K27Mmutant tumors were associated with longer overall survival in 13 high-grade infiltrating gliomas, by Kaplan–Meier curves and the log-rank test [23]; on pair-wise comparison, no significant difference in the overall survival was found between patients with H3K27Mmutant and H3K27M-wildtype tumors (or between H3K27M-mutant and TERT promoter-mutant tumors).