Among 28 high-grade gliomas, the relation between survival and age, gender, tumor grade, treatment modality, extent of resection (EOR), p53 expression, and MIB-1 LI were analyzed by Kaplan–Meier curves and the log-rank test: only age higher than 40 years resulted as significant negative prognostic factor [9]. The gene discussed is MIB1; the disease is central nervous system cancer.