Many previous studies demonstrated the involvement of LMP1 in modulating the composition of the immunological environment in favor of a long-life infection persistence through regulating the expression of chemokines (CCL17, CCL22), cytokines (IL6, hIL-10), adhesion, and costimulatory molecules (CD18, ICAM, CD80), genes regulating antigen processing and presentation (HLA I, II) [65,66,67,68]. Here, IL6 is linked to infection.