A pivotal study of 7559 patients undergoing genomic sequencing on a 236 or 315 cancer-related gene panel demonstrated that the most common genomic alterations in SBA were TP53 (58.4%), KRAS (53.6%), APC (26.8%), SMAD4 (17.4%), PIK3CA (16.1%), CDKN2A (14.5%), and ARIDIA (12.3%) [1]. This evidence concerns the gene CDKN2A and cancer.