Similarly, those with germline inactivation of the APC gene, associated with familial adenomatous polyposis (FAP), have a 4.5% lifetime risk of developing SBA [33,34,35], while those with an inherited STK11 mutation, resulting in Peutz-Jeghers syndrome (PJS), have a relative risk of 520 for developing SBA [36]. Here, STK11 is linked to Familial adenomatous polyposis.