Finally, the observations that (1) eIF4E expression correlated with hnRNP H1, hnRNP H2, hnRNP F and A-Raf (r = 0.474, r = 0.321, r = 0.409 and r = 0.457 in the Ivy GBM database (http://glioblastoma.alleninstitute.org/ accessed on 17 May 2021), respectively), and (2) A-Raf full length mRNA is overexpressed in GBM primary and recurrent solid tumors (mining of the TCGA splicing variants database), support a potential clinical importance of the hnRNP H/F–A-Raf–eIF4E axis in GBM, thus making hnRNP H/F a potential target for therapeutic intervention. Here, EIF4E is linked to glioblastoma.