MAP2K7 and glioblastoma: In agreement with previous findings reporting that A-Raf short protein negatively regulates the Ras-MAPK(Raf-MEK-ERK) pathway [37], we found that hnRNP H and/or hnRNP F silencing significantly decreased the phosphorylation of ERK 1/2 compared with the total ERK 1/2 amount in LN18 GBM cells (Figure 1C,D).