In particular, the eukaryotic translation initiation factor 4E (eIF4E) is hyperactivated via phosphorylation downstream of the MAPK-interacting serine/threonine kinases (MNKs) [15,16] and by mTOR-dependent inactivation of its negative regulators—tumor-suppressive eIF4E-binding proteins (4E-BPs) [17]. Here, EIF4E is linked to neoplasm.