The study showing that eIF4E phosphorylation favors cancer cell resistance to TMZ [30], together with our results (Figure 1), support interesting future investigations to determine whether the effect of hnRNP H/F on phosphorylated eIF4E constitutes one of the mechanisms underlying the impact of hnRNP H/F on GBM resistance to treatment. The gene discussed is EIF4E; the disease is glioblastoma.