IGF1R and colorectal cancer: To date, a number of client mRNAs for IGF2BP2 have been identified in several cancers, including insulin-like growth factor 1 receptor in prostate cancer [26], Zinc-finger E-box binding protein 1 in gastric cancer [27], High-mobility group A1 in colorectal cancer [28], etc. The m6A motifs are typically enriched in the 3′-UTR and CDS, regulating precursor mRNA maturation, translation, and degradation [29].