TPO and thyroid cancer: Detailed analysis of public TCGA database from cBioPortal (http://cancergenome.nih.gov, accessed on 3 August 2020) showed that the expression of all the key m6A “writers”, “erasers”, and “readers”, and the iodide-handling genes (NIS, TPO, TSHR, and TG) were significantly different between normal thyroid tissues and thyroid cancer tissues (Figure 1A and Supplementary Table S2).