TF and neoplasm: Next, we combined the direct and indirect regulators and constructed models following two objectives, i.e., (i) selecting direct TERT regulators with which the model fit best the expression profiles of TERT across all investigated tumor samples (best fit of MIPRIP), and (ii) obtaining the most densely connected regulatory module (highest modularity) when adding TF from the pre-selected twenty-seven indirect TERT regulators.