These direct regulators (Figure 1E, marked in red) were most often found in models with the 14 indirect regulators E2F4, MAZ, POLR2A, POU2F2, SMARCB1, TAF1, REST, PML, SMC3, ZNF263, EP300, YY1, MAFK, and USF1 leading to our final gene regulatory network module for TERT in PCa (Figure 1E). The gene discussed is REST; the disease is posterior cortical atrophy.