PITX1 and posterior cortical atrophy: Chromatin immunoprecipitation (ChIP) showed that PITX1 directly binds to the TERT promoter at the −1.3kb region in the PCa cell lines LNCaP and C4–2 (Figure 3D) since upon knockdown of PITX1, PITX1 bound to the DNA was significantly decreased, validating our predictions.