Indeed, the activation of EGFR produces the detachment by SRC-mediated phosphorylation of the p120/E-CAD complex from the low-density lipoprotein receptor-related protein 5/6 (LRP5/6), which together with the frizzled receptors (FZD), activates the Wnt signalosome favoring the tumor cell growth [21]. The gene discussed is LRP5; the disease is neoplasm.