EGFR and non-small cell lung carcinoma: Currently there are ongoing clinical trials further exploring multimodal treatment strategies for patients with stage IV disease, such as the LONESTAR trial investigating the role of local consolidation therapy in patients receiving nivolumab and ipilimumab [91], or the NORTHSTAR trial investigating the role of local consolidation therapy in patients with EGFR mutant advanced/metastatic NSCLC receiving osimertinib [92].