By analyzing longer follow-up data of the NPC-2003-GPOH study and expanding the study cohort by 21 equally treated interim patients, we add further support to our multimodal treatment concept with cisplatin-based induction chemotherapy, combined radiochemotherapy, and subsequent IFN-β maintenance as standard of care for children and young adults with newly diagnosed NPC. The gene discussed is IFNB1; the disease is nasopharyngeal carcinoma.