A further similarity not only to other marginal-zone B-cell lymphomas, but also to various other lymphoma types (e.g., many diffuse large B-cell lymphomas and Hodgkin lymphoma), is the major role of constitutive NF-κB activity, mediated by various types of chromosomal translocations and mutations in proto-oncogenes and tumor-suppressor genes [129]. This evidence concerns the gene NFKB1 and B-cell non-Hodgkin lymphoma.