EPAS1 and esophageal squamous cell carcinoma: Eight variations in EPAS1 (c.1084C>T, c.1099C>A, c.1145_1145delT, c.1093C>G, c.1121T>G, c.1137_1137delG, c.1135_1136insT, c.1091_1092insT) were recently detected in 6 out of 80 patients (7.5%) with esophageal squamous cell carcinomas, with the majority of patients carrying these variations experiencing a deregulation of EPAS1 [177].