According to a genomic study of a subset of RADIANT everolimus trials [248], patients with high chromosomal instability (CIN) showed a trend toward longer OS (HR, 0.55; p = 0.077), even after adjusting for baseline CgA/NSE levels (HR, 0.53; p = 0.068). This evidence concerns the gene ENO2 and cervical squamous intraepithelial neoplasia.