In addition, either the presence of MEN-1 (Multiple Endocrine Neoplasia-type 1) mutations, or mutations of DAXX (death-domain-associated protein) or ATRX (alpha thalassemia/mental retardation syndrome X-linked), did not improve OS with everolimus treatment (p = 0.34) [248]. Here, DAXX is linked to Alpha-thalassemia.