JAK2 and neoplasm: However, markers related to myelomonocytic cells and MDSCs (i.e., VCAM1, NLRP3, JAK2) were also highly expressed in patients with dMMR, as well as CD36, a protein involved in M2 macrophage activation, and PI3Kγ, which is suggested to be involved in the immunomodulatory activity of tumor-associated myeloid subsets.