CDK12 and neoplasm: A subset of lethal PCas (20–30%), including those with defective homologous recombination DNA repair genes, defective mismatch repair (dMMR) genes, DNA polymerase epsilon (POLE) mutations, and cyclin-dependent kinase 12 (CDK12) biallelic alterations, have been variably associated with higher tumor mutational burden (TMB) and neoantigen load, which may arguably increase the likelihood of antitumor immunity [7,26].