Given these results, several clinical trials are specifically investigating the efficacy of ICI in mCRPC biomarker-selected patients, such as HRD-positive tumors, CDK12-inactivated tumors, MSI-high tumors, and several others, which might represent promising predictive and prognostic factors (Table 2) able to offer a more accurate patient selection in the rapidly evolving therapeutic scenario of advanced PCa. This evidence concerns the gene CDK12 and posterior cortical atrophy.