TGFB1 and neoplasm: NHS-IL12 is a tumor-targeting immunocytokine that results in the delivery of IL-12 to the TME, while bintrafusp alfa is a bifunctional fusion protein that targets both TGFβ and PD-L1 by fusing the extracellular domain of TGFβ receptor II to a human immunoglobulin G1 antibody blocking PD-L1 (NCT04756505) (Table 2) [108,109].