Thus, BRCAness may lie in aberration of the genes BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C and RAD51D, and, in ovarian cancer, BRCA1 or BRCA2 mutation predicts the high sensitivity to platinum-based chemotherapy and PARPi, leading to an increased overall survival [5]. The gene discussed is BRCA1; the disease is ovarian cancer.