CAFs also protect pancreatic cancer cells from gemcitabine-induced apoptosis through a NF-κB→IL-1β→IL-1R/associated kinase-4 (IRAK4) pathway; inhibition of IL-1β, or knockdown of IRAK4, dramatically augment gemcitabine chemosensitivity [115]. The gene discussed is IRAK4; the disease is pancreatic neoplasm.