There is also a strong positive correlation between CAF α-SMA and PAI-1 colocalization in human lung adenocarcinoma [192], and PAI-1 distributes to α-SMA-positive fibroblastoid cells at the invasive margins and stroma-enriched regions in cutaneous squamous cell carcinomas (Figure 3). The gene discussed is ACTA1; the disease is lung adenocarcinoma.