Elevated PAI-1 expression, moreover, stimulates migration of tumor cells as well as macrophages and increases tumor invasion through a LRP1/PI3K/AKT signaling cascade, while incubation of ESCC cells with Tiplaxtinin attenuates PI3K and AKT phosphorylation and reduces resistance to cisplatin in vitro. This evidence concerns the gene SERPINE1 and neoplasm.