IL-6 secretion by esophageal squamous cell carcinoma (ESCC) CAFs, furthermore, increases upon coculture with tumor cells, activating STAT3/NF-κB signaling leading to an induction in CXCR7 expression enhancing chemoresistance to cisplatin [116]. The gene discussed is ACKR3; the disease is esophageal squamous cell carcinoma.