Elevated PAI-1 expression, moreover, stimulates migration of tumor cells as well as macrophages and increases tumor invasion through a LRP1/PI3K/AKT signaling cascade, while incubation of ESCC cells with Tiplaxtinin attenuates PI3K and AKT phosphorylation and reduces resistance to cisplatin in vitro. Here, SERPINE1 is linked to esophageal squamous cell carcinoma.