Similarly, in bladder cancer, the miRNA-143/-145 cluster, which recognizes the 3’-UTR of PAI-1, is attenuated in all disease stages leading to PAI-1 upregulation [272], while in human osteosarcoma mouse models injection of miRNA-143 suppressed lung metastasis [273]. The gene discussed is SERPINE1; the disease is urinary bladder carcinoma.