CAFshighα5 promote tumor cell interaction with the provisional fibronectin–collagen matrix, and α5β1 is involved in spheroid maintenance [86] since targeting heterotypic spheroids, constructed with OVCA cell lines and mesothelial cells, with ITGB1-specific antibodies or ITGB1 siRNA resulted in a loss of spheroid integrity in vitro [98]. This evidence concerns the gene ITGB1 and neoplasm.