High levels of SOD3 in the milieu of EG7-SOD3 tumors grafted in syngeneic mice or EG7 tumors implanted in SOD3EC-Tg mice were also correlated with a reduction in laminin α5 staining intensity in tumor blood vessels, supporting a role for SOD3/LAMA5 interactions in vivo. The gene discussed is LAMA5; the disease is neoplasm.