Similarly, in Kirsten rat sarcoma (RAS) mutant pancreatic cancers, the RAS oncogene binds, through its RAS-responsive element-binding (RREB1), the promoter of the miR-143/145 family, which normally act as repressors of the same RAS and RREB1 transcription factors. Here, RREB1 is linked to familial pancreatic carcinoma.