As an example, trimethylation at H3K27 represses the production of CXCL9 and CXCL10 in ovarian cancer, establishing an immune-suppressive TME [134], while DNMT1 is responsible for the diminution of CXCL12 in osteosarcomas, resulting in reduced CTL recruitment at the cancer site [135]. The gene discussed is DNMT1; the disease is cancer.