STAT3 and cancer: A further example is breast cancer, where a proinflammatory microenvironment at the distant metastatic site, particularly enriched in IL-6 and prostaglandin E2 (PGE2), promotes DNMT3B induction, thus altering the methylation of multiple pathways involved in cancer cell survival, apoptosis, and invasion, including signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), PI3K/Akt, b-catenin, and Notch signaling.