In addition, Zhang et al. [51] showed a positive correlation between ARG1 expression and histone lactylation in tumor-associated macrophages (TAMs) isolated from melanoma and lung tumor cells and suggested, as previously proposed by Colegio et al. [128], that lactate can regulate TAM polarization toward an M2-like phenotype and, consequentially, have an important role in tumor growth. The gene discussed is ARG1; the disease is neoplasm.