Besides, as expected from the observed TNT stimulatory effect of PI3K/Akt/mTOR signaling, inhibition of mTOR activity, by rapamycin or by the rapamycin derivative everolimus, suppressed TNT formation in murine astrocytes and human mesothelioma MSTO-211H cells, respectively [32,58]. This evidence concerns the gene MTOR and mesothelioma.