These include the plasma membrane Ca2+ ATPase (ATP2B4) [43], the purinergic receptor subtype P2RY2A [44] and the calcium channel ORAI1 [45], all upregulated in colon cancer and the calcium voltage-gated channels CACNA1H and CACNA1Cn were found to be downregulated in colon cancer [46]. This evidence concerns the gene ORAI1 and malignant colon neoplasm.