Found in up to 90% of CRC patients, APC gene inactivating mutations promote the initiation of CRC [5], whereas KRAS gene mutations have been detected in approximately 40% of CRC patients, seemed to occur during all stages of CRC [6,7] and were found to mediate colon cancer initiation through CSCs activation [7]. The gene discussed is KRAS; the disease is malignant colon neoplasm.